J. Wesche

Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping.

This study shows ex vivo anticoagulants affect platelet biomechanics and demonstrates their impact on mechanophenotyping in a MYH9-related disorder.

Alpha-hemolysin of Staphylococcus aureus impairs thrombus formation

This study shows that Staphylococcus aureus alpha-hemolysin activates and then damages platelets, impairing thrombus formation and stability, and is not neutralized by polyvalent immunoglobulins.

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

This study identifies GAK and PRKCD as positive regulators of PRKN-independent mitophagy through genetic screening and functional analysis in vitro and in vivo.

A cell competition-based drug screen identifies a novel compound that induces dual c-Myc depletion and p53 activation

This study identifies a novel compound, DJ34, that depletes c-Myc and activates p53, showing strong activity against leukemic stem cells across multiple cancer types.

The phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors

The paper identifies PTPRG as a phosphatase that dephosphorylates FGFR1, enhancing FGFR inhibitor sensitivity in osteosarcoma cells.