Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis
A. Halama, M. Kulinski, S. S. Dib, S. B. Zaghlool, K. S. Siveen, A. Iskandarani, N. J. Satheesh, A. M. Bhagwat, S. Uddin, G. Kastenmueller, O. Elemento, S. S. Gross, K. Suhre
The paper shows that inhibiting glutaminolysis in cancer cells leads to lipid catabolism and autophagy, which promote survival, and that combined inhibition of both pathways can induce cell death.
bioRxiv · Jan 15, 2018Cancer Biology