Oncoprotein GT198 is a direct target of taxol
Z. Yang, V. J. Gurvich, M. L. Gupta, N. F. Mivechi, L. Ko
This study identifies GT198 as a direct target of taxol, showing it binds to GT198's DNA-binding domain and inhibits its function, which may explain taxol's efficacy and side effects in cancer treatment.
bioRxiv · Jun 19, 2019 · PreprintPharmacology & Toxicology