Author

L. Ko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1

Frequent Co-Authors

L. Zhang· 2 shared N. F. Mivechi· 2 shared Z. Yang· 2 shared A. S. Arbab· 1 shared B. R. Achyut· 1 shared B. W. O'Malley· 1 shared C. Zhao· 1 shared H. Zhang· 1 shared

Activity by Year

2019-2019 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPathology

L. Zhang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mutant GT198 in angiogenesis as a common origin of human prostate and bladder cancers

L. Zhang, Y. Liu, L. Cheng, C. Zhao, L. Ko

This study identifies GT198 mutations in stromal cells as a common cause of prostate and bladder cancers and suggests GT198 as a therapeutic target.

bioRxiv · Aug 6, 2019 · PreprintPathology

Oncoprotein GT198 Vaccination Delays Tumor Growth in MMTV-PyMT Mice

B. R. Achyut, H. Zhang, K. Angara, N. F. Mivechi, A. S. Arbab, L. Ko

This study shows that vaccinating MMTV-PyMT mice with GT198 protein delays tumor growth and reduces metastasis, suggesting a shared tumorigenic pathway between human and mouse cancers.

bioRxiv · Jul 5, 2019Cancer Biology

Oncoprotein GT198 is a direct target of taxol

Z. Yang, V. J. Gurvich, M. L. Gupta, N. F. Mivechi, L. Ko

This study identifies GT198 as a direct target of taxol, showing it binds to GT198's DNA-binding domain and inhibits its function, which may explain taxol's efficacy and side effects in cancer treatment.

bioRxiv · Jun 19, 2019 · PreprintPharmacology & Toxicology

Oncoprotein CoAA repeats interact with RNA polymerase II CTD repeats

S. Xiong, Y. S. Brooks, Z. Yang, J. Wu, L. Zhang, W. S. Dynan, W. Xu, B. W. O'Malley, L. Ko

This study shows that the oncoprotein CoAA interacts with RNA polymerase II CTD repeats, explaining the functional requirement of diheptad repeats in transcription and alternative splicing.

bioRxiv · Jun 13, 2019 · PreprintBiochemistry