IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity
R. Lang, S. Wirtz, D. Voehringer, M. Lacorcia, M. Altunay, B. Bodendorfer, C. Schubart, D. Christensen, C. Alexander, J. Schick, C. P. da Costa
This study shows IL-4 and helminth infection reduce MINCLE expression on macrophages, impairing Th17 responses to MINCLE-based vaccines.
bioRxiv · Aug 17, 2021Immunology