ImmunologybioRxiv
IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity
R. Lang, S. Wirtz, D. Voehringer…·C. P. da Costa
This study shows IL-4 and helminth infection reduce MINCLE expression on macrophages, impairing Th17 responses to MINCLE-based vaccines.
DOI 10.7554/elife.72923