Antibiotic production in Streptomyces is organized by a division of labour through terminal genomic differentiation
Z. Zhang, C. Du, F. de Barsy, M. Liem, A. Liakopoulos, G. van Wezel, Y. H. Choi, D. Claessen, D. Rozen
The paper shows that Streptomyces coelicolor colonies use division of labour to enhance antibiotic production by generating specialized mutants that trade individual fitness for increased secondary metabolite diversity and yield.
bioRxiv · Jun 28, 2019Evolutionary Biology