C. Du

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex

This paper shows that CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex capable of synthesizing cellulose in vitro.

Systems-wide analysis of the ROK-family regulatory gene rokL6 and its role in the control of glucosamine toxicity in Streptomyces coelicolor

The paper identifies RokL6 as a regulator that controls the expression of the MFS transporter SCO1448, which protects Streptomyces coelicolor from glucosamine toxicity by exporting toxic metabolites.

An RGB based deep neural network for high fidelity Fusarium head blight phenotyping in wheat

This paper introduces an RGB-based deep neural network for high-fidelity Fusarium head blight phenotyping in wheat, achieving accuracy comparable to human scoring and demonstrating strong generalizability across field conditions.

PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

Bioengineering of a Lactococcus lactis subsp. lactis strain enhances nisin production and bioactivity.

This study enhances nisin production and antimicrobial activity in Lactococcus lactis subsp. lactis through genetic modifications involving nisA, nisRK, and nisZ genes.

The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes

This paper shows that plant hormones jasmonic acid and methyljasmonate alter growth, development, and antibiotic production in Streptomyces, with amino acid conjugation inactivating the hormone as a bacterial defense mechanism.

Prevalent regulation of GATA2/3 and MSX2 on endogenous retrovirus-derived regulatory elements in human trophoblast stem cells

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry

This study uses native mass spectrometry and molecular dynamics to show how intrinsically disordered CTDs in Hfq form a network that integrates RNA contacts and stabilizes the hexamer.

Salicin modifies osteoarthritis progression by binding on IRE1α and inhibiting IRE1α mediated endoplasmic reticulum stress

Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance

This paper identifies YM201636 and PI-103 as potent TPC2 channel blockers and shows His699 near the pore entrance is critical for their inhibitory effect.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

New from old: discovery of the novel antibiotic actinomycin L in Streptomyces sp. MBT27

This paper discovers novel actinomycin derivatives, L1 and L2, produced by Streptomyces sp. MBT27 through metabolic analysis and molecular networking, showing their unique biosynthesis involving two metabolic pathways.

Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance

This study shows that inhibiting adenine synthesis with L-Alanosine reduces stemness and temozolomide resistance in MTAP-deficient glioblastoma cells by impairing mitochondrial function.

Effect of SARS-CoV-2 spike mutations on animal ACE2 usage and in vitro neutralization sensitivity

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

lncRNA-RMST functioned as a SOX2 transcription co-regulator to regulate miR-1251 in the progression of Hirschsprung's disease

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products

The paper introduces decRiPPter, a machine learning and pan-genomic approach to discover novel RiPP classes, identifying 42 new candidate families from Streptomyces genomes.

Potential host range of multiple SARS-like coronaviruses and an improved ACE2-Fc variant that is potent against both SARS-CoV-2 and SARS-CoV-1

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

Juvenile hormone regulation on the flight capability of Bactrocera dorsalis (Diptera: Tephritidae)

This study investigates how juvenile hormone (JH) regulates flight capability in Bactrocera dorsalis, finding that JH levels correlate with flight duration and distance, and that JH III treatment enhances flight performance.

Fundamental contribution and host range determination of ANP32 protein family in influenza A virus polymerase activity

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

Antibiotic production in Streptomyces is organized by a division of labour through terminal genomic differentiation

The paper shows that Streptomyces coelicolor colonies use division of labour to enhance antibiotic production by generating specialized mutants that trade individual fitness for increased secondary metabolite diversity and yield.

ANP32A and ANP32B are key factors in the Rev dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA

This study identifies ANP32A and ANP32B as essential host factors that facilitate HIV-1 unspliced RNA export via the Rev-CRM1 pathway.

Structural and biochemical characterization on the cognate and heterologous interactions of the MazEF-mt9 TA system

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.