Non-Canonical Regulation of Phosphatidylserine Metabolism by a Phosphatidylinositol Transfer Protein and a Phosphatidylinositol 4-OH Kinase
Y. Wang, P. Yuan, A. Tripathi, M. Rodriguez, M. Lonnfors, M. Eisenberg-Bord, M. Schuldiner, V. Bankaitis
The paper shows that Psd2-dependent phosphatidylethanomaine production in yeast relies on Psd2, Sfh4, and Stt4, with Sfh4 activating the pathway through a physical interaction rather than its PtdIns transfer activity.
bioRxiv · Jul 8, 2019Cell Biology