A. Tripathi

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve Injury

This study shows Sarm1 promotes the transition from protective to repair Schwann cell states after nerve injury, with implications for neuropathies and neurodegenerative diseases.

Nrf2 regulates the activation-driven expansion of CD4+ T-cells by differentially modulating glucose and glutamine metabolism

This study shows Nrf2 modulates CD4+ T-cell activation and expansion by altering glucose and glutamine metabolism, offering insights for improving immunotherapies.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

A negative feedback loop is critical for recovery of RpoS after stress in Escherichia coli.

The paper shows that a negative feedback loop involving RpoS and rssB is critical for restoring RpoS degradation after stress in E. coli.

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

This study investigates the role of TgLaforin, a glucan phosphatase, in Toxoplasma gondii by showing its impact on glucan metabolism, virulence, and bradyzoite survival during chronic infection.

Poly-basic peptides and polymers as new drug candidate against Plasmodium falciparum

This study shows poly-lysine peptides and their modifications can reduce Plasmodium falciparum in human erythrocytes in vitro, with potential as new antimalarial drugs.

Unique interactions and functions of the mitochondrial small Tims in Trypanosoma brucei

This study identifies unique interactions and functional roles of small TbTims in the TbTIM17 complex of T. brucei, revealing distinct complex architectures and dynamics.

Expression of Microcystis biosynthetic gene clusters in natural populations suggests temporally dynamic synthesis of novel and known secondary metabolites in western Lake Erie

The paper analyzes Microcystis BGCs in western Lake Erie cyanoHABs to show dynamic expression of known and novel secondary metabolites linked to environmental factors.

Distribution of the gyromitrin mycotoxin in the lorchel family assessed by a pre-column-derivatization and ultra high-performance liquid chromatography method

The paper detects gyromitrin in multiple lorchel species using a derivatization method and phylogenetic analysis, showing its distribution is discontinuous and limited.

Mechanisms by Which Small Molecule Inhibitors Arrest Sec14 Phosphatidylinositol Transfer Protein Activity

This study investigates how small molecule inhibitors affect Sec14 phosphatidylinositol transfer protein activity using structural analysis to inform antifungal drug design.

Combined MD and QM/MM Calculations reveal Allostery Driven Promiscuity in Dipeptide Epimerases of Enolase Family

The paper shows how a mutation far from the active site can induce conformational changes to enhance enzyme promiscuity through allostery.

Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant

This study uses untargeted metabolomics to analyze exogenous chemicals in human milk and finds they are present in newborn stool, indicating potential infant exposure through breastfeeding.

Screening the Pathogen Box Compounds for Activity Against Plasmodium falciparum Sporozoite Motility

This study screens 400 drug-like compounds from the Pathogen Box for activity against Plasmodium falciparum sporozoite motility and identifies five compounds with significant inhibitory effects.

IFN-induced protein with tetratricopeptide repeats 2 (Ifit2) limits autoimmune inflammation by regulating myeloid cell activation and metabolic activity

This study identifies Ifit2 as a regulator of myeloid cell activation and metabolic activity, which limits autoimmune inflammation in EAE.

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota

This study shows that xanthan gum, a common food additive, promotes the adaptation of the human gut microbiota by enabling a novel degradation pathway in an uncultured Ruminococcaceae bacterium and facilitating cross-feeding by Bacteroides species.

Trypanosoma brucei Tim50 Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity

This study shows that TbTim50 is essential for mitochondrial function, kDNA replication, and cell cycle regulation in Trypanosoma brucei, and its depletion reduces parasite infectivity.

Coordinated action of RTBV and RTSV proteins suppress host RNA silencing machinery

This study shows RTBV ORF-IV suppresses RNA silencing and its activity is enhanced by RTSV proteins, contributing to Tungro disease severity.

Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen

The paper evaluates a new malaria transmission-blocking vaccine antigen, UF6b, showing it induces potent antibodies against a key epitope and is immunogenic in mice.

Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice

This paper shows that Mtb's SufR senses NO via its 4Fe-4S cluster, regulates Fe-S cluster biogenesis, and supports persistence in mice.

A Sec14-like Phosphatidylinositol Transfer Protein Paralog Defines a Novel Class of Heme-binding Proteins With An Unusual Heme Coordination Mechanism

The paper identifies Sfh5 as a novel heme-binding protein with an unusual coordination mechanism, distinct from its Sec14-like PITP family members.

The Atlas of Inflammation-Resolution (AIR)

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.

Non-Canonical Regulation of Phosphatidylserine Metabolism by a Phosphatidylinositol Transfer Protein and a Phosphatidylinositol 4-OH Kinase

The paper shows that Psd2-dependent phosphatidylethanomaine production in yeast relies on Psd2, Sfh4, and Stt4, with Sfh4 activating the pathway through a physical interaction rather than its PtdIns transfer activity.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.

Petrobactin protects against oxidative stress and enhances sporulation efficiency in Bacillus anthracis Sterne

This paper shows petrobactin is required for efficient sporulation and oxidative stress protection in B. anthracis Sterne, even with ample iron, and is involved in transmission via spores in natural infections.

Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages

This paper uses untargeted mass spectrometry to analyze chemical changes in foods during preparation and storage, finding that some processes alter molecular composition while others primarily involve extraction.