Alpha-toxin elicited CX3CL1-release via ADAM10 in Staphylococcus aureus pneumoniaimpairs bactericidal function of human monocytes
S. Mairpady Shambat, P. Chen, R. M. Barilla, M. Huemer, J. Snaell, A. Welin, T. S. Cohen, V. Takahashi, S. B. Berry, A. Gomez-Mejia, T. A. Schweizer, D. M. Cunoosamy, S. Cajander, M. Lourdaa, V. Ozenci, , M. Svensson
This study shows that S. aureus alpha-toxin induces CX3CL1 release via ADAM10 in lung epithelium, impairing monocyte bactericidal function through CX3CL1-dependent mechanisms.
bioRxiv · Sep 17, 2023 · PreprintMicrobiology