Author

T. A. Schweizer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Assay:proteomics· 3 Assay:whole-genome sequencing· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. S. Zinkernagel· 7 shared S. D. Brugger· 6 shared S. Mairpady Shambat· 6 shared M. Boumasmoud· 4 shared M. Huemer· 4 shared A. Gomez-Mejia· 3 shared C. Acevedo· 3 shared C. Vulin· 3 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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7 shared papersMicrobiology

A. S. Zinkernagel

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Alpha-toxin elicited CX3CL1-release via ADAM10 in Staphylococcus aureus pneumoniaimpairs bactericidal function of human monocytes

S. Mairpady Shambat, P. Chen, R. M. Barilla, M. Huemer, J. Snaell, A. Welin, T. S. Cohen, V. Takahashi, S. B. Berry, A. Gomez-Mejia, T. A. Schweizer, D. M. Cunoosamy, S. Cajander, M. Lourdaa, V. Ozenci, , M. Svensson

This study shows that S. aureus alpha-toxin induces CX3CL1 release via ADAM10 in lung epithelium, impairing monocyte bactericidal function through CX3CL1-dependent mechanisms.

bioRxiv · Sep 17, 2023 · PreprintMicrobiology

Group A Streptococcus strains causing meningitis without distinct invasive phenotype

L. Marquardt, F. Andreoni, M. Boumasmoud, T. A. Schweizer, D. Heuberger, E. Parietti, S. Hertegonne, J. Epprecht, D. Mattle, A. Raez, E. Marques-Maggio, R. Schuepbach, B. K. Hasse, S. Mairpady Shambat, S. D. Brugger, A. Zinkernagel

This study compares GAS strains from meningitis and otitis cases, finding no distinct invasive traits associated with meningitis.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

Intervertebral disc cell chondroptosis elicits neutrophil response in Staphylococcus aureus spondylodiscitis

T. A. Schweizer, F. Andreoni, C. Acevedo, T. C. Scheier, I. Heggli, E. Marques Maggio, N. Eberhard, S. D. Brugger, S. Dudli, A. S. Zinkernagel

This study investigates S. aureus spondylodiscitis by combining clinical data and an ex vivo porcine model, showing IVD cell death and neutrophil recruitment.

bioRxiv · Jan 31, 2022Immunology

Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically-ill COVID-19 patients

S. Mairpady Shambat, A. Gomez-Mejia, T. A. Schweizer, M. Huemer, C.-C. Chang, C. Acevedo, J. Bergada Pijuan, C. Vulin, N. Miroshnikova, D. A. Hofmanner, P. D. Wendel Garcia, M. P. Hilty, P. K. Buehler, R. A. Schuepbach, S. D. Brugger, A. S. Zinkernagel

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

PLOS Pathogens · Jan 10, 2022Peer-reviewedImmunology

Limited adaptive evolution of Staphylococcus aureus during transition from colonization to invasive infection

A. K. Räz, F. Andreoni, M. Boumasmoud, J. Bergada Pijuan, T. A. Schweizer, S. Mairpady Shambat, B. K. Hasse, A. S. Zinkernagel, S. D. Brugger

The paper compares phenotypic and genotypic profiles of S. aureus colonizing and invasive isolates, finding limited genetic evolution and similar traits, with barrier disruption as key to disease progression.

bioRxiv · Oct 25, 2021Microbiology

Quantification of within patient Staphylococcus aureus phenotypic heterogeneity as a proxy for presence of persisters across clinical presentations

J. Baer, M. Boumasmoud, S. Mairpady Shambat, C. Vulin, M. Huemer, T. A. Schweizer, A. Gómez Mejia, N. Eberhard, Y. Achermann, P. O. Zingg, C. A. Mestres, S. D. Brugger, R. A. Schüpbach, R. D. Kouyos, B. Hasse, A. S. Zinkernagel

This study quantifies phenotypic heterogeneity in Staphylococcus aureus from patient samples to assess persisters, finding that rifampicin treatment correlates with increased growth delays.

bioRxiv · Jul 27, 2021Microbiology

Genomic surveillance of vancomycin-resistant Enterococcus faecium reveals spread of a linear plasmid conferring a nutrient utilization advantage

M. Boumasmoud, V. Dengler Haunreiter, T. A. Schweizer, L. Meyer, B. Chakrakodi, P. W. Schreiber, K. Seidl, D. Kühnert, R. D. Kouyos, A. S. Zinkernagel

This study identifies a linear plasmid in vancomycin-resistant Enterococcus faecium that confers a nutrient utilization advantage, contributing to its spread in a hospital setting.

bioRxiv · May 7, 2021Microbiology

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

T. A. Schweizer, S. Mairpady Shambat, C. Vulin, S. Hoeller, C. Acevedo, M. Huemer, A. Gomez-Mejia, C.-C. Chang, J. Baum, S. Hertegonne, E. Hitz, D. A. Hofmaenner, P. K. Buehler, H. Moch, R. A. Schuepbach, , A. S. Zinkernagel

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

bioRxiv · Mar 19, 2021 · PreprintImmunology