P. Chen

α2A-AR-Kv dysfunction drives LC hyperactivity and early sleep disturbance in amyloidogenic mice

This study identifies LC hyperactivity driven by α2A-AR and Kv channel dysfunction as a cause of early sleep disruption in 5xFAD mice.

Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide

This study shows that glycerol metabolism in oral commensal streptococci produces hydrogen peroxide, enhancing competition against the pathogen Streptococcus mutans.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites

This study screens over 30,000 compounds to identify new anthelmintics effective against gastrointestinal nematodes, finding 55 compounds with broad-spectrum activity.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Determining the Youngs Modulus of the Bacterial Cell Envelope

The paper measures the Young's modulus of bacterial cell envelopes in E. coli, V. cholerae, and S. aureus using a microfluidic system and inverse finite element analysis, finding values ranging from 0.12 to 2.06 MPa.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Gentle rhodamines for live-cell fluorescence microscopy

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

A "through-DNA" mechanism for metal uptake-vs.-efflux regulation

The paper reveals a through-DNA mechanism where ZntR influences Zur's DNA binding kinetics, enabling coordinated metal uptake and efflux regulation in E. coli.

Multifrequency control of Faraday wave bioassembly for constructing multiscale hPSC-derived neuronal networks

This paper introduces a multifrequency Faraday wave bioassembly technique to create multiscale neuronal networks from hPSCs, demonstrating spontaneous neuroelectrical activity.

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

A 3D Printed Ventilated Perfused Lung Model Platform to Dissect the Lung's Response to Viral Infection in the Presence of Respiration

This study develops a 3D printed lung model to investigate how ventilation affects viral infection and lung responses in vitro.

Alpha-toxin elicited CX3CL1-release via ADAM10 in Staphylococcus aureus pneumoniaimpairs bactericidal function of human monocytes

This study shows that S. aureus alpha-toxin induces CX3CL1 release via ADAM10 in lung epithelium, impairing monocyte bactericidal function through CX3CL1-dependent mechanisms.

Evolutionary prediction for new echolocators

The paper predicts three new mammalian echolocators using molecular convergence analyses and machine learning, with behavioral experiments confirming echolocation in shrew moles.

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19

This study identifies dysregulated immune-epithelial progenitor interactions in post-viral lung sequelae and shows that targeting IFN-γ, TNF, or IL-1β improves alveolar regeneration and pulmonary function.

Fungal-bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

The paper investigates fungal-bacterial interactions in CSD, finding that fungal species alter bacterial abundance through metabolites, contributing to dysbiosis.

Estimating foraging behavior in rodents using a modified paradigm measuring threat imminence dynamics

The paper modifies a threat imminence paradigm to study foraging behavior in rodents, showing it is influenced by age, hunger, and sex.

Induction of plant disease resistance by mixed oligosaccharide elicitors prepared from plant cell wall and crustacean shells

This study compares the elicitor activities of different oligosaccharides from plant cell walls and crustacean shells, showing that a mixture enhances disease resistance in tomato without inhibiting growth.

Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model

The paper validates a new ISS model for estimating insulin sensitivity and beta-cell function from OGTTs, showing strong correlation with gold-standard methods across diverse populations.

Neuregulin-1 protects against respiratory viral induced mortality

This study shows that Neuregulin-1 (NRG1) protects against respiratory viral mortality by reducing viral replication and epithelial permeability in both mice and human cells.

Nuclear growth and import can be uncoupled

The paper shows nuclear growth and import can be uncoupled, suggesting chromatin mechanical properties drive nuclear growth rather than import alone.

Amoeboid cells undergo durotaxis with soft end polarized NMIIA

The paper shows amoeboid cells, like T cells and neutrophils, can durotax by polarizing NMIIA towards softer substrates, and this behavior is conserved in Dictyostelium.

Clostridium butyricum and Clostridium tyrobutyricum: angle or devil for Necrotizing enterocolitis?

This study compares the effects of Clostridium butyricum and Clostridium tyrobutyricum on Necrotizing enterocolitis in mice, finding that C. tyrobutyricum alleviates inflammation and improves intestinal barrier integrity, while C. butyricum worsens these conditions.

High-Throughput Bioprinting of the Nasal Epithelium using Patient-derived Nasal Epithelial Cells

This study uses 3D bioprinting to create nasal epithelium models from patient-derived cells, enabling high-throughput fabrication and recapitulating native epithelial architecture and virus infection capability.

Terrestrial Support of Aquatic Food Webs via an Overlooked Pathway-Inorganic Carbon and its Significance to Global Carbon Cycle

The paper quantifies the role of dissolved inorganic carbon (DIC) from terrestrial organic matter decomposition in supporting aquatic food webs and highlights its significance to global carbon cycling in seasonal wetlands.

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

This study uses single-cell RNA sequencing and network analysis to identify cell type-specific gene dysregulation mechanisms in type 2 diabetes.

Expansion microscopy with trypsin digestion and tyramide signal amplification (TT-ExM) for protein and lipid staining

The paper introduces TT-ExM, an improved expansion microscopy technique that reduces protein loss and enhances fluorescence signals through trypsin digestion and tyramide signal amplification, enabling ultrafine-resolution imaging of cellular structures.

Transcriptomic analysis of diverse organisms reveals the rareness of genetic assimilation in environmental adaptations

The paper analyzes transcriptomic data from diverse organisms to show that genetic assimilation is rare in environmental adaptations.

Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis

This study identifies fibroblast-derived extracellular vesicles containing SFRP1 that contribute to pulmonary fibrosis and suggests SFRP1 as a therapeutic target.