Structural basis for endotoxin neutralization and anti-inflammatory activity of thrombin-derived C-terminal peptides
R. Saravanan, D. A. Holdbrook, J. Petrlova, S. Singh, N. A. Berglund, Y. K. Choong, P. J. Bond, M. Malmsten, A. Schmidtchen
This paper identifies the structural basis of thrombin-derived C-terminal peptides' ability to neutralize endotoxin and reduce inflammation by interacting with LPS and CD14.
bioRxiv · Dec 12, 2017Biophysics