The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place
O. Villafraz, H. Baudouin, M. Mazet, H. Kulyk, J.-W. Dupuy, E. Pineda, C. Y. Botte, D. Inaoka, J.-C. Portais, F. Bringaud
This study shows that UDP-glucose pyrophosphorylase (UGP) is imported into glycosomes by piggybacking on phosphoenolpyruvate carboxykinase (PEPCK) and that both cytosolic and glycosomal UGP pathways are functional in trypanosomes.
bioRxiv · Feb 17, 2021Microbiology