J.-C. Portais

This study shows that weak neuronal glycolysis supports cognition and organismal fitness by preventing mitochondrial redox stress and maintaining autophagy.

This study shows that Cytidine deaminase (CDA) promotes mitochondrial biogenesis and oxidative phosphorylation in pancreatic cancer cells, independent of its deaminase activity, revealing new therapeutic targets.

This study identifies MDH2 as a metabolic switch that regulates NADH oxidation in the respiratory chain and TCA cycle by modulating OAA production and complex I/II activity.

This study shows that UDP-glucose pyrophosphorylase (UGP) is imported into glycosomes by piggybacking on phosphoenolpyruvate carboxykinase (PEPCK) and that both cytosolic and glycosomal UGP pathways are functional in trypanosomes.

This study shows procyclic trypanosomes can use TCA cycle intermediates and glucose catabolites for growth in the fly midgut, expanding their metabolic flexibility.

The paper introduces a new mechanism called 'metabolic contest' that regulates carbon source preference in trypanosomes without nutrient sensing or signaling.