Pharmacological characterization of the endocannabinoid sensor GRABeCB2.0
S. Singh, D. Sarroza, A. English, M. McGrory, A. Dong, L. Zweifel, B. B. Land, Y. Li, M. Bruchas, N. Stella
This study characterizes the pharmacological response of the GRABeCB2.0 sensor to endocannabinoids and cannabinoids, finding that its EC50 values for 2-AG and SR1 match CB1R potencies, while others show lower EC50s, and CBD acts as a negative allosteric modulator.
bioRxiv · Mar 3, 2023Pharmacology & Toxicology