The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity
H. Mamar, R. Fajka-Boja, M. Morocz, E. P. Jurado, S. Zentout, A. Mihut, A. G. Kopasz, M. Merey, R. Smith, L. Haracska, S. Huet, G. Timinszky
This study shows that loss of POLE4 leads to PARP inhibitor sensitivity independent of BRCA1, through replication stress and DNA-PK signaling changes.
bioRxiv · Sep 21, 2023 · PreprintCell Biology