Cell BiologybioRxivPreprint
The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity
H. Mamar, R. Fajka-Boja, M. Morocz…·G. Timinszky
This study shows that loss of POLE4 leads to PARP inhibitor sensitivity independent of BRCA1, through replication stress and DNA-PK signaling changes.
DOI 10.1101/2023.09.21.558850