A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
P. Wiriyasermkul, S. Moriyama, M. Suzuki, P. Kongpracha, N. Nakamae, S. Takeshita, Y. Tanaka, A. Matsuda, M. Miyasaka, K. Hamase, T. Kimura, M. Mita, J. Sasabe, S. Nagamori
The paper identifies two renal D-serine transport systems, revealing ASCT2 as a noncanonical substrate of SMCTs and highlighting their physiological and pathological roles.
bioRxiv · Aug 10, 2020Biochemistry