T. Kimura

ZIP13 regulates lipid metabolism by changing intracellular iron and zinc balance

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

Characterization of the placenta-specific EnvV2-Fca soluble protein derived from endogenous retrovirus

This study identifies and characterizes EnvV2-Fca, a placenta-specific protein from an endogenous retrovirus in cats, and explores its evolutionary and potential zoonotic implications.

FeLIX is a restriction factor for mammalian retrovirus infection

The paper identifies soluble truncated Env proteins from endogenous FeLV as antiviral restriction factors that inhibit retrovirus infection through competitive receptor binding.

Human intestinal organoid-derived PDGFRα+ mesenchymal stroma empowers LGR4+ epithelial stem cells

This study shows that organoid-derived mesenchymal stromal cells support the proliferation and functionality of hPSC-derived small intestinal epithelial stem cells in adherent culture.

A novel in silico scaffold-hopping method for drug repositioning in rare and intractable diseases

This paper introduces a novel in silico scaffold-hopping method for drug repositioning, identifying 144 compounds with potential new therapeutic applications for rare diseases.

Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells

This study isolates and expands hepatic progenitor cells from human ESCs by selecting for drug-metabolizing activity, enabling a stable supply of functional liver cells for therapy and drug testing.

The gradient-based parameter optimization to determine membrane ionic current composition of human induced pluripotent stem cell-derived cardiomyocytes

The paper develops a gradient-based optimization method to recover ionic current conductances from action potentials of hiPSC-CMs, showing convergence to the original parameter values.

A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells

The paper presents a method to expand and profile genetically edited murine hematopoietic stem cells at clonal density to reduce genetic heterogeneity before transplantation.

Manipulating Histone Acetylation Leads to Adverse Effects in Hemangiosarcoma Cells

This study investigates the effects of histone acetylation manipulation using HDACi and BETi on canine hemangiosarcoma cells, finding that SAHA and JQ1 induce apoptosis and anti-tumour immunity, while JQ1 inhibits proliferation.

Hypothesis: Colony-forming activity of pluripotent stem cell-derived hepatocyte-like cells for stem cell assay

The paper hypothesizes that colony-forming units in liver (CFU-L) can quantify the engraftment and functionality of hepatocyte-like cells derived from pluripotent stem cells.

Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

This study identifies ISOS-1 as a syngeneic mouse model for canine hemangiosarcoma and shows that tumor-associated macrophages are M2-polarized and express PD-L1, contributing to immune evasion.

Tracheal motile cilia in mice require CAMSAP3 for formation of central microtubule pair and coordinated beating

This study shows CAMSAP3 is essential for forming the central microtubule pair in tracheal motile cilia and enabling coordinated beating in mice.

Drug metabolism activity is a Critical Intrinsic Selector for Hepatocytes to elongate cell lifespan by using a cell-killing antibiotic

This study develops a method to expand human hepatocytes in vitro using a cell-killing antibiotic, enabling long-term culture and stable supply for drug research.

Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior

The paper investigates how the luminal surface structure of decellularized aorta affects thrombus formation and cell behavior, finding that structures closer to native aorta show better anti-coagulant properties and cell recognition.

The Phosphorylation Status of NPH3 Affects Photosensory Adaptation During the Phototropic Response

The study shows that phosphorylation of NPH3 affects its subcellular localization and the photosensory adaptation of phot1 signaling during phototropism.

KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

This study shows KDM2B promotes canine hemangiosarcoma cell viability by enhancing DNA damage response and suggests GSK-J4 as a potential therapeutic alternative.

A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

The paper identifies two renal D-serine transport systems, revealing ASCT2 as a noncanonical substrate of SMCTs and highlighting their physiological and pathological roles.

Puromycin selection of cells with a high expression of the cytochrome P450 CYP3A4 gene activity from a patient with drug-induced liver injury (DILI) and their lifespan prolongation using a combination of CDK4R24C, cyclin D1 and TERT

The paper generates an immortalized hepatocyte cell line with high CYP3A4 expression from a DILI patient and shows its prolonged lifespan and drug-metabolism capacity.

Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells

This study shows that ammonia treatment enriches hepatocyte-like cells derived from human pluripotent stem cells, which can be propagated long-term in vitro while maintaining liver-specific gene expression.

Arabidopsis ROOT PHOTOTROPISM2 is a Light-Dependent Dynamic Modulator of Phototropin1

This study identifies RPT2 as a light-dependent modulator of phot1 activity in Arabidopsis, showing it suppresses phot1's photosensitivity and kinase activity through LOV1 inhibition and ubiquitin-proteasome regulation.

Immortalization of human zone I hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing

The paper describes the creation of an immortalized hepatocyte cell line, HepaMN, from biliary atresia tissue and demonstrates its utility for cytochrome P450 induction testing.

miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4 and CHORDC1

This study identifies miR-26a as a regulator of extracellular vesicle secretion in prostate cancer cells by targeting SHC4, PFDN4, and CHORDC1, which inhibits tumor progression.