M. Suzuki

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

This study develops a live-attenuated SARS-CoV-2 vaccine candidate, BK2102, which induces long-term immunity and is safe in animal models.

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

Pathophysiological Significance of Impaired KAT7-Dependent Histone H3K14 Acetylation During Zinc Deficiency

The paper shows that zinc deficiency impairs KAT7-dependent H3K14ac at enhancers, upregulating ZIP10 and lipid droplet genes in mice, linking zinc homeostasis to epigenetic regulation.

Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation

This study develops a suspension culture method for hiPSCs using PKCβ and Wnt inhibitors to prevent spontaneous differentiation, enabling scalable and stable clinical-grade hiPSC production.

Genome-resolved meta-omics unveils rock-hosted lifestyle of enigmatic DPANN archaea

This study investigates the lifestyle of DPANN archaea in rock-hosted environments using genome-resolved meta-omics, revealing a symbiotic lifestyle and ecological interactions with bacteria and minerals.

Genetic and immune determinants of E. coli liver abscess formation

This study identifies host genetic and immune factors that determine susceptibility to E. coli liver abscesses in mice using spatial and single-cell transcriptomics.

Assessing the performance of the Cell Painting assay across different imaging systems

The paper evaluates Cell Painting assay performance across different imaging systems, finding compatibility and identifying optimal settings for each.

Significant SAR11 removal by a hard-bottom community

The study examines microbial taxon removal by benthic filter-feeders in hard-bottom communities and finds no significant differential removal of SAR11 bacteria.

Gross anatomy of the Pacific hagfish, Eptatretus burgeri, with special reference to the coelomic viscera

This study describes the gross anatomy of Eptatretus burgeri, highlighting differences in branchial pores and coelomic organs compared to Myxine glutinosa.

The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1alpha-dependent recruitment and differentiation of pro-tumor ICOShiGITRhi Blimp-1+ effector regulatory T cells in breast tumors

This study shows that MLL3/TP53/PIK3CA mutations in breast tumors promote immunosuppressive Treg cell differentiation via HIF1alpha, leading to tumor growth and suggesting therapeutic targets.

Strand-biased circularizing integrative elements spread tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps by repeated transpositions

The paper identifies a mobile genetic element, SE, that mediates the spread of tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps through transposition in bacteria.

Emergence of plasmid-mediated RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis in a water environment

This study identifies a mobile RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis from a water environment, contributing to multidrug resistance.

Enterococcal linear plasmids adapt to Enterococcus faecium and spread within multidrug-resistant clades.

This study identifies enterococcal linear plasmids that spread AMR genes through horizontal transfer and contribute to multidrug resistance in Enterococcus faecium.

Castration alters the circadian clock and Ucp1 expression in subcutaneous white adipose tissue of mice

This study shows that castration in mice increases Ucp1 expression in subcutaneous white adipose tissue and disrupts circadian clock gene expression, suggesting a link between castration, circadian rhythms, and thermogenic changes.

Cardiac-Gated Spectroscopic Photoacoustic Imaging for Ablation-Induced Necrotic Lesion Visualization: In Vivo Demonstration in a Beating Heart

This paper demonstrates cardiac-gated spectroscopic photoacoustic imaging for visualizing ablation-induced necrotic lesions in a beating heart using a swine model.

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

Density-dependent attributes of schooling in small pelagic fishes

The paper examines density-dependent schooling behaviors in three small pelagic fish species, finding species-specific relationships between population density and school characteristics.

Cell tip growth underlies injury response of marine macroalgae

This study investigates regeneration mechanisms in marine macroalgae after injury, finding tip cell growth and varied nuclear dynamics across species.

A Novel Cytoskeletal Action of Xylosides

The paper shows that low concentrations of xylosides affect neuronal cell morphology by altering cytoskeletal dynamics without impacting GAG synthesis or gene expression.

Differential cellular stiffness contributes to tissue elongation on an expanding surface

This study investigates how differential cellular stiffness, through area elasticity, influences tissue elongation in an expanding environment, supported by comparisons to mouse notochord development.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

Photothermal Dye-based Subcellular-sized Heat Spot Enabling the Modulation of Local Cellular Activities

The paper introduces nanoHT, a photothermal nanoparticle that creates subcellular heat spots to modulate cellular activities, inducing cell death and muscle contraction in specific areas.

Inferring the Demographic History of Japanese Eel (Anguilla japonica) from Genomic Data: Insights for Conservation and Fisheries Management

This study infers the demographic history of Japanese eel using genomic data, revealing population bottlenecks and growth periods linked to environmental changes.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.

Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data

This paper predicts chemical toxicities using induced pluripotent stem cells and gene networks via transfer learning from embryonic stem cell data, achieving high accuracy across multiple toxicity categories.

Bcr4 is a Chaperone for the Inner Rod Protein in the Bordetella Type III Secretion System

This paper identifies Bcr4 as a chaperone that stabilizes BscI, an inner rod protein of the T3SS, enabling T3SS function in B. bronchiseptica.

Emergence of a novel mobile RND-type efflux pump gene cluster, tmexC3D2-toprJ1b, in Pseudomonas species

The paper identifies a novel tmexC3D2-toprJ1b gene cluster conferring tigecycline resistance in Pseudomonas species, acquired via horizontal gene transfer.

A transferable IncC-IncX3 hybrid plasmid co-carrying blaNDM-4, tet(X4), and tmexCD3-toprJ3 confers resistance to carbapenem and tigecycline

The paper identifies a multidrug-resistant plasmid in Klebsiella aerogenes that carries genes for carbapenem and tigecycline resistance and shows its potential for global spread.