Molecular Mechanisms Underlying Medium-Chain Free Fatty Acid-regulated Activity of the Phospholipase PlaF from P. aeruginosa
R. Gentile, M. Modric, B. Thiele, K.-E. Jaeger, F. Kovacic, S. Schott-Verdugo, H. Gohlke
This study investigates how medium-chain free fatty acids regulate PlaF activity through molecular dynamics simulations and free energy computations, revealing mechanisms of dimerization and activation.
bioRxiv · May 2, 2023 · PreprintBiophysics