Chimeric protein EWS-FLI1 drives cell proliferation in Ewing Sarcoma via overexpression of KCNN1.
M. Dupuy, M. Gueguinou, A. Postec, R. Brion, R. Tesfaye, M. Mullard, L. Regnier, J. Amiaud, M. Potier-Cartereau, A. Chantome, B. Brounais-Le Royer, M. Baud'huin, S. Georges, F. Lamoureux, B. Ory, , F. Verrecchia
This study identifies KCNN1 as a target of EWS-FLI1 and EWS-ERG fusion proteins in Ewing Sarcoma, showing its role in cell proliferation and potential as a therapeutic target.
bioRxiv · Apr 24, 2023 · PreprintCancer Biology