Author

C. Vandier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Gueguinou· 4 shared A. Robert· 3 shared D. Crottes· 3 shared G. Fromont-Hankard· 2 shared J. Bourgeais· 2 shared J.-F. Dumas· 2 shared M. Potier-Cartereau· 2 shared O. Herault· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

M. Gueguinou

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5 papers

Recent·Most cited

Investigation of the heterogeneity of cancer cells using single cell calcium profiling.

A. Bura, C. Caussette, M. Gueguinou, D. Bellanger, A. Robert, M. Cancel, M. Lacouette-Rata, G. Fromont-Hankard, C. Vandier, K. Maheo, T. Brouard, D. Crottes

This study uses single cell calcium profiling combined with machine learning to analyze Ca2+ signature heterogeneity in cancer cells and their remodeling during resistance and cell interactions.

bioRxiv · Jan 14, 2024Cancer Biology

Encoding of the colorectal cancer metabolic program through MICU2

A. Robert, D. Crottes, J. Bourgeais, N. Gueguen, A. Chevrollier, J.-F. Dumas, S. Servais, I. Domingo, S. Chadet, J. Sobilo, O. Herault, T. Lecomte, C. Vandier, W. Raoul, M. Gueguinou

This study investigates the role of MICU2 in colorectal cancer metabolism, showing its importance in mitochondrial function, metabolic flexibility, and tumor progression.

bioRxiv · Oct 31, 2023 · PreprintCancer Biology

Chimeric protein EWS-FLI1 drives cell proliferation in Ewing Sarcoma via overexpression of KCNN1.

M. Dupuy, M. Gueguinou, A. Postec, R. Brion, R. Tesfaye, M. Mullard, L. Regnier, J. Amiaud, M. Potier-Cartereau, A. Chantome, B. Brounais-Le Royer, M. Baud'huin, S. Georges, F. Lamoureux, B. Ory, , F. Verrecchia

This study identifies KCNN1 as a target of EWS-FLI1 and EWS-ERG fusion proteins in Ewing Sarcoma, showing its role in cell proliferation and potential as a therapeutic target.

bioRxiv · Apr 24, 2023 · PreprintCancer Biology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology

CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer

D. O'Reilly, T. J. Downing, S. Kouba, M. Potier-Cartereau, D. McKenna, C. Vandier, P. J. Buchanan

This study shows that increased CaV1.3 promotes resistance to androgen deprivation in prostate cancer by enhancing store operated calcium entry.

bioRxiv · Sep 3, 2021Cancer Biology