Senescence inhibits the chaperone response to thermal stress
J. Llewellyn, V. Mallikarjun, E. Appleton, M. Osipova, H. T. Gilbert, S. M. Richardson, S. J. Hubbard, J. Swift
The paper shows that senescence impairs the chaperone response to thermal stress in human mesenchymal stem cells, leading to misfolded protein accumulation.
bioRxiv · Jun 15, 2021 · PreprintCell Biology