Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
J. Yong, J. E. Villalta, N. Vu, M. A. Kukurugya, N. Olsson, M. P. Lopez, J. R. Lazzari-Dean, K. Hake, F. McAllister, B. D. Bennett, C. H. Jan
The paper identifies lipid homeostasis as a regulator of proteostasis, showing that lipid dysregulation disrupts ESCRT function and causes lysosomal protein aggregation.
bioRxiv · Nov 23, 2022 · PreprintCell Biology