J. Yong

The paper identifies lipid homeostasis as a regulator of proteostasis, showing that lipid dysregulation disrupts ESCRT function and causes lysosomal protein aggregation.

This study investigates calcium-independent ER-PM contact site oscillations in RBL mast cells and their role in SOCE, showing PI(4)P dependency and the importance of reversible contact sites for calcium oscillations.

This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.

This paper develops a quantitative method and optimizes culture conditions to significantly increase the biomass of the fastidious bacterium Christensenella minuta.

The paper identifies a Ca2+-antagonized mechanism for ATP transport into the ER and links ER ATP usage to an anti-Warburg metabolic effect.