Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions
G. Moquin-Beaudry, B. Benabdalah, D. Maggiorani, O. Le, Y. Li, C. Colas, C. Raggi, B. Ellezam, M. M'Callum, D. Dal Soglio, J. V. Guimond, M. Paganelli, E. Haddad, C. Beausejour
This paper develops autologous humanized mouse models of iPSC-derived tumors to study and modulate cancer-immune interactions, showing immune infiltration and response to PD-1 inhibition.
bioRxiv · Apr 2, 2021Cancer Biology