E. Haddad

Guild and Niche Determination Enable Targeted Alteration of the Microbiome

This study introduces a method to classify microbes into guilds and predict their niche preferences using metatranscriptomic and metatranslatomic data, enabling targeted microbiome manipulation.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Generation of Functional Human T Cell Development in NOD/SCID/IL2rγnull Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and Persistence

This paper introduces a new humanized mouse model using cord blood-derived CD34+ cells and pediatric thymic tissue that supports functional T cell development and HIV infection and persistence.

Genome-wide CRISPR Screens Identify Ferroptosis as a Novel Therapeutic Vulnerability in Acute Lymphoblastic Leukemia

This study identifies ferroptosis as a therapeutic vulnerability in B-ALL through genome-wide CRISPR screens and validates it in patient-derived samples.

Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

This paper develops autologous humanized mouse models of iPSC-derived tumors to study and modulate cancer-immune interactions, showing immune infiltration and response to PD-1 inhibition.

Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike

This study evaluates humoral responses against SARS-CoV-2 Spike in 106 infected individuals, finding persistent RBD-specific IgG and declining neutralizing activity over time.

NK cells prevent the formation of teratomas derived from human induced pluripotent stem cells

This study shows that NK cells prevent teratoma formation from hiPSCs in immune competent hosts, while autologous T cells can reject established teratomas.

Immune tolerance of human induced pluripotent stem cell-derived myogenic progenitor cells in humanized mice

This study evaluates immune tolerance of hiPSC-derived myogenic progenitor cells in humanized mice, finding autologous cells are tolerated while allogeneic grafts are rejected, and NK cell transfer prevents teratoma formation.

The tumor immune response is not compromised by mesenchymal stromal cells in humanized mice

This study shows that human umbilical cord mesenchymal stromal cells do not affect tumor growth or immune rejection in humanized mice.

Efficient and robust NK-Cell transduction with Baboon Envelope pseudotyped lentivector: a major tool for immunotherapy

This paper demonstrates that Baboon Envelope pseudotyped lentiviral vectors efficiently transduce NK-cells, enabling CAR expression and specific killing of cancer cell lines.