Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423 and Hey2
C. Barone, M. Buccarelli, F. Alessandrini, M. Pagin, L. Rigoldi, I. Sambruni, R. Favaro, S. Ottolenghi, R. Pallini, L. Ricci-Vitiani, P. Malatesta, S. K. Nicolis
This study identifies four genes, Cdkn2b, Ebf1, Zfp423, and Hey2, whose inhibition by Sox2 is critical for maintaining glioma cancer stem cell properties, suggesting new therapeutic targets.
bioRxiv · Mar 4, 2020Cancer Biology