Author

M. Pleska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:ecology & biodiversity· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Guet· 2 shared B. R. Levin· 1 shared C. C. Guet· 1 shared G. Tkacik· 1 shared J. R. Gurney· 1 shared J. Ruess· 1 shared M. Lang· 1 shared N. Nikolic· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

C. Guet

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Bacterial toxin-antitoxin system MazEF as a native defense mechanism against RNA phages in Escherichia coli

N. Nikolic, T. Bergmiller, M. Pleska, C. Guet

This study shows that the MazEF toxin-antitoxin system in E. coli protects against RNA phages by cleaving their genomes, with MazF targeting specific sequences in phage genomes.

bioRxiv · Feb 1, 2023Microbiology

Population dynamics of decision making in temperate bacteriophages

M. Lang, M. Pleska, C. C. Guet

The paper develops a stochastic model to study how temperate bacteriophages make decisions between lysis and lysogeny during coinfections, finding that coinfections provide limited population-level information but can offer competitive advantages.

bioRxiv · Mar 18, 2020 · PreprintEvolutionary Biology

Molecular noise of innate immunity shapes bacteria-phage ecologies

J. Ruess, M. Pleska, C. Guet, G. Tkacik

This study uses mathematical models to show how molecular stochasticity in bacterial immunity affects population-level ecological outcomes and optimal defense strategies against phages.

bioRxiv · Jan 15, 2019Biophysics

Why Put-Up with Immunity when there is Resistance: An Excursion into the Population and Evolutionary Dynamics of Restriction-Modification and CRISPR-Cas

J. R. Gurney, M. Pleska, B. R. Levin

This study uses mathematical models and simulations to analyze when bacteria's immune systems (RM and CRISPR-Cas) are favored over envelope resistance against phage infections.

bioRxiv · Dec 8, 2018Evolutionary Biology