Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference
V. Lobo, I. Nowak, C. Fernandez, A. I. Correa Muler, J. O. Westholm, H.-C. Huang, I. Fabrik, H. T. Huynh, E. Shcherbinina, M. Poyraz, A. Hartlova, D. Benhalevy, D. Angeletti, A. A. Sarshad
This study shows that loss of Lamin A causes AGO2 to move into the nucleus, impairing RNAi and increasing oncogenic miRNA expression in cancer cells.
bioRxiv · Jun 5, 2023Biochemistry