H.-C. Huang

The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.

This study shows that loss of Lamin A causes AGO2 to move into the nucleus, impairing RNAi and increasing oncogenic miRNA expression in cancer cells.

This paper develops a biomimetic nanodrug targeting YAP/TAZ in atherosclerotic plaques, showing reduced plaque development in mice with minimal off-target effects.

This study identifies distinct in vivo properties and functions of large and small extracellular vesicles in breast cancer, showing their differential biodistribution and tumorigenic potential.

This study identifies chemical probes that induce reductive stress and shows that reductive stress and peptide accumulation together strongly activate NLRP1 and CARD8 inflammasomes.

This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

The paper characterizes epigenetic alterations in esophageal cancer using whole-genome bisulfite sequencing and identifies novel clusters and molecular features in two subtypes.

This study identifies two distinct thymic macrophage populations with different locations and origins using single-cell RNA sequencing and genetic fate mapping.

This study develops a sphere-forming assay to isolate a malignant subpopulation from a CRC cell line and identifies DPEP1 as a prognostic biomarker.