Vaginal squamous cell carcinoma develops in mice with Arid1a loss and gain of oncogenic Kras
X. Wang, M. Praca, J. R. H. Wendel, R. Emerson, F. DeMayo, J. Lydon, S. M. Hawkins
This study shows that combining Arid1a loss and KrasG12D expression in mice leads to invasive vaginal squamous cell carcinoma, highlighting the need for both genetic hits to drive gynecologic malignancy.
bioRxiv · Dec 15, 2020 · PreprintCancer Biology