Inflammatory cytokines rewire the proinsulin interaction network in human islets
D. Tran, A. Pottekat, K. Lee, M. Raghunathan, S. Loguercio, S. A. Mir, A. W. Paton, J. C. Paton, P. Arvan, R. J. Kaufman, P. Itkin-Ansari
This study identifies how inflammatory cytokines alter the proinsulin interactome in human islets, revealing new interactions and mechanisms involved in diabetes-related proinsulin dysregulation.
bioRxiv · Apr 7, 2022Cell Biology