D. Tran

Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling In Vivo

The paper shows how actin filaments dynamically adjust their structure to control membrane transfer between cellular compartments in live rodents.

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

This study shows that pre-existing CMV immunity in nonhuman primates reduces placental transmission and fetal loss during reinfection compared to primary infection.

SARS-CoV-2 Envelope-mediated Golgi pH dysregulation interferes with ERAAP retention in cells

This study identifies SARS-CoV-2 Envelope protein-induced Golgi pH neutralization as a mechanism causing ERAAP loss and extracellular release, highlighting ERAAP as a sensor of secretory pathway disturbances during infection.

Inflammatory cytokines rewire the proinsulin interaction network in human islets

This study identifies how inflammatory cytokines alter the proinsulin interactome in human islets, revealing new interactions and mechanisms involved in diabetes-related proinsulin dysregulation.

Balancing growth amidst salinity stress-lifestyle perspectives from the extremophyte model Schrenkiella parvula

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

Adjuvant and immunomodulatory potential of Natural Killer T (NKT) activation by NKTT320

This study evaluates the adjuvant and immunomodulatory effects of NKTT320, a humanized monoclonal antibody that activates iNKT cells, showing enhanced immune responses and inflammation resolution.

Transduction of mechanical cellular oscillation by the plasma-membrane mechanosensitive channel MSL10

The paper shows that MSL10, a mechanosensitive channel in Arabidopsis, responds to mechanical oscillations with rapid activation and behaves as an oscillation follower in the 0.3-3 Hz range.

PD-L1 expression in 522 selected sarcomas with subset analysis of recurrent or metastatic matched samples and association with tumour-infiltrating lymphocytes

This study evaluates PD-L1 expression in 522 sarcomas, finding variability across subtypes and demonstrating increased PD-L1 in some metastatic/recurrent samples, suggesting potential for immune checkpoint inhibitor therapy.

Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing

This study shows that centrioles affect the capacity but not the specificity of cytotoxic T cell killing by impacting granule biogenesis and actin remodeling, not granule polarization.

Impact of preexisting virus-specific maternal antibodies on cytomegalovirus population genetics in a monkey model of congenital transmission

This study examines how maternal antibodies affect CMV genetic diversity in a monkey model, finding no impact on viral genetic diversity despite reduced viral load and congenital transmission.

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

This study shows that preexisting antibodies can prevent congenital cytomegalovirus infection in monkeys by blocking placental transmission.