Abcc6 null mice a model for mineralization disorder PXE show vertebral osteopenia without enhanced intervertebral disc calcification with aging
P. Boneski, V. Madhu, R. Tomlinson, K. Van de Wetering, I. Shapiro, M. Risbud
This study investigates ABCC6 loss-of-function in mice, showing reduced vertebral bone quality and mild disc degeneration without disc calcification, and suggests potassium citrate as a potential treatment.
bioRxiv · Nov 17, 2021Cell Biology