Cell BiologybioRxiv
Abcc6 null mice a model for mineralization disorder PXE show vertebral osteopenia without enhanced intervertebral disc calcification with aging
P. Boneski, V. Madhu, R. Tomlinson…·M. Risbud
This study investigates ABCC6 loss-of-function in mice, showing reduced vertebral bone quality and mild disc degeneration without disc calcification, and suggests potassium citrate as a potential treatment.
DOI 10.3389/fcell.2022.823249