Pyruvate dehydrogenase kinase expression profile is a biomarker for cancer sensitivity to dichloroacetate-mediated growth inhibition.
B. P. Gang, M. Rooke, R. C. Sun, S. Banskota, S. Mishra, J. E. Dahlstrom, A. C. Blackburn
This study identifies PDK expression profiles as a biomarker for cancer sensitivity to DCA, showing that low PDK3 expression correlates with higher DCA sensitivity.
bioRxiv · Sep 18, 2023 · PreprintCancer Biology