Somatic Mutations Predict Acute Myeloid Leukemia Years Before Diagnosis
P. Desai, N. Mencia-Trinchant, O. Savenkov, M. S. Simon, G. Cheang, S. Lee, M. Samuel, E. K. Ritchie, M. L. Guzman, K. V. Ballman, G. J. Roboz, D. C. Hassane
This study identifies somatic mutations in peripheral blood that predict acute myeloid leukemia (AML) years before diagnosis, with TP53 mutations showing the strongest association and earliest onset.
bioRxiv · Dec 21, 2017Cancer Biology