M. Sane

Mutation bias alters the distribution of fitness effects of mutations

The paper tests how changing mutation bias affects the distribution of fitness effects in E. coli, finding that reversing the mutation bias increases the proportion of beneficial mutations.

Mutational signatures in wild type Escherichia coli strains reveal dominance of DNA polymerase errors

The paper analyzes mutational signatures in E. coli strains to show DNA polymerase errors, not DNA repair disruptions, drive mutation accumulation in both natural and lab settings.

Shifts in mutation spectra enhance access to beneficial mutations

The paper shows that changing mutation spectra in E. coli increases beneficial mutations and reduces deleterious load, with simulations indicating that bias shifts are selectively favored.

Antagonistic pleiotropy is unexpectedly rare in new mutations

The paper quantifies pleiotropy in E. coli mutations and finds antagonistic pleiotropy is rare and not consistently linked to large-effect mutations.