Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption
C. Umansky, A. Morellato, M. Scheidegger, M. Rieckher, M. R. Martinefski, G. A. Fernandez, K. Kolesnikova, A. J. Vesting, I. Karakasilioti, H. Reingruber, Y. Wei, R. He, M. Bollini, M. E. Monge, B. Schumacher, L. B. Pontel
This study shows endogenous formaldehyde disrupts cellular redox homeostasis by reacting with glutathione, and ADH5 prevents this by regenerating reduced glutathione.
bioRxiv · May 14, 2020Cell Biology