R. He

Genotypic-phenotypic landscape computation based on first principle and deep learning

The paper develops a deep learning framework to map genotypes to fitness, applies it to predict viral mutations and immune escape, and computes the genotype-fitness landscape for SARS-CoV-2.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut

This study shows that IL-23 receptor signaling in ILC3s enables them to produce IFNγ and clear the live-attenuated oral Chlamydia vaccine intrOv from the gut, ensuring its safety.

SIDERITE: Unveiling Hidden Siderophore Diversity in the Chemical Space Through Digital Exploration

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

Ferroptosis is determined by chloride ions

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

Induction of transmucosal protection by oral vaccination with an attenuated Chlamydia

This study evaluates an attenuated Chlamydia muridarum mutant as an oral vaccine that induces transmucosal immunity against genital and airway infections but not gastrointestinal colonization.

Spike-specific CXCR3+ TFH cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

Biosynthetic diversification of peptaibol mediates fungus-mycohost interactions

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

MIG-23 is involved in sperm migration in Ascaris suum

This study identifies MIG-23 as a key regulator of sperm migration in Ascaris suum by modulating extracellular ATP levels through ecto-ATPase activity.

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

Emergence of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Co-harbouring a blaNDM-1-carrying Virulent Plasmid and a blaKPC-2-carrying Plasmid in an Egyptian Hospital

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

The influence of positive emotion and negative emotion on false memory based on EEG signals analysis

This study examines how positive and negative emotions affect false memory using EEG, finding higher false memory rates and distinct brain activation patterns in the positive emotion group.

Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption

This study shows endogenous formaldehyde disrupts cellular redox homeostasis by reacting with glutathione, and ADH5 prevents this by regenerating reduced glutathione.

Accumulation of ammonium owing to the metabolic imbalance of carbon and nitrogen might inhibit the central metabolism in Methylomonas sp. ZR1

This study investigates how ammonium accumulation from nitrogen and carbon metabolism imbalance inhibits growth in Methylomonas sp. ZR1 and identifies strategies to mitigate this inhibition.

High-throughput sequencing analysis of bacterial diversity in raw and pasteurized goat milk

This study compares bacterial diversity in raw and pasteurized goat milk using high-throughput sequencing, identifying new bacterial species and viable but nonculturable bacteria.

Screening and functional analysis of differentially expressed genes in an animal model of EBV-associated lymphomas

The paper identifies 202 differentially expressed genes in EBV-induced lymphomas using a mouse model and highlights key genes involved in the oncogenic process.

Super-resolution imaging reveals changes in Escherichia coli SSB localization in response to DNA damage.

This study uses super-resolution imaging to show that E. coli SSB relocates from the inner membrane to the cell interior in response to DNA damage, forming foci for repair.