Effect of RNA m6A methyltransferase activation by a low molecular weight compound on anxiety- and depression-related behaviours, monoamine neurochemistry and striatal gene expression in the rat
M. Kanarik, K. Liiver, M. Skolnaja, I. Teino, T. Org, K. Laugus, R. Shimmo, M. Karelson, M. Saarma, J. Harro
This study examines the effects of CHMA1004, a METTL3/METTL14 activator, on anxiety, depression, and striatal gene expression in rats, finding increased locomotor activity and anxiolytic-like effects.
bioRxiv · Jan 8, 2024 · PreprintPharmacology & Toxicology