Author

M. Saarma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Karelson· 3 shared I. Teino· 2 shared L. Ivanova· 2 shared A. Buskirk· 1 shared A. Eesmaa· 1 shared B. Beckert· 1 shared D. Blokhina· 1 shared D. N. Wilson· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

M. Karelson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis

H. Takada, H. Paternoga, K. Fujiwara, J. A. Nakamoto, E. N. Park, L. Dimitrova-Paternoga, B. Beckert, M. Saarma, T. Tenson, A. Buskirk, G. C. Atkinson, S. Chiba, D. N. Wilson, V. Hauryliuk

This study identifies YlmH as a novel RQC factor in B. subtilis, showing it can replace RqcP in polyalanine tail addition and is conserved in bacteria lacking RqcP.

bioRxiv · Mar 3, 2024 · PreprintMicrobiology

Effect of RNA m6A methyltransferase activation by a low molecular weight compound on anxiety- and depression-related behaviours, monoamine neurochemistry and striatal gene expression in the rat

M. Kanarik, K. Liiver, M. Skolnaja, I. Teino, T. Org, K. Laugus, R. Shimmo, M. Karelson, M. Saarma, J. Harro

This study examines the effects of CHMA1004, a METTL3/METTL14 activator, on anxiety, depression, and striatal gene expression in rats, finding increased locomotor activity and anxiolytic-like effects.

bioRxiv · Jan 8, 2024 · PreprintPharmacology & Toxicology

Novel RNA m6A methyltransferase METTL16 inhibitors

S. Selberg, L. Ivanova, M. Kotli, K. Herodes, D. Blokhina, E. Kankuri, N. Seli, I. Ilves, I. Teino, M. Saarma, M. Karelson

This study identifies two nanomolar METTL16 inhibitors that reduce leukemia cell viability and m6A levels in HL-60 cells.

bioRxiv · Mar 27, 2023 · PreprintPharmacology & Toxicology

MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α

V. Kovaleva, L.-Y. Yu, L. Ivanova, J. Nam, A. Eesmaa, E.-P. Kumpula, J. Huiskonen, P. Lindholm, M. H. Voutilainen, M. Karelson, M. Saarma

This study identifies MANF's mechanism of action through its interaction with IRE1α, showing it modulates UPR and protects neurons from ER stress.

bioRxiv · Sep 22, 2020 · PreprintCell Biology

Cell cycle-balanced expression of pluripotency regulators via cyclin-dependent kinase 1

S. Kasvandik, R. Schilf, M. Saarma, M. Loog, K. Jaager

The paper investigates how CDK1 activity regulates the expression dynamics of pluripotency regulators in mouse ESCs, showing that CDK1 maintains a specific S to G2M expression ratio.

bioRxiv · Oct 9, 2019 · PreprintCell Biology