Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation
X. Jia, Y. K.- Y. Chin, A. H. Zhang, T. Crawford, Y. Zhu, N. L. Fletcher, Z. Zhou, B. R. Hamilton, M. Stroet, K. J. Thurecht, M. Mobli
This paper introduces autocyclase proteins that enable efficient self-cyclisation of peptides and proteins, producing cyclic biomolecules with high yields and avoiding challenges of enzymatic methods.
bioRxiv · Jul 12, 2022Biochemistry