X. Jia

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

Diaminopurine in Nonenzymatic RNA Template Copying

This study investigates whether replacing adenine with diaminopurine in nonenzymatic RNA template copying improves efficiency and reduces bias.

Biological management, rather than chemical management, promotes the interaction between plants and their microbiome

This study identifies potato cultivars that promote beneficial interactions with rhizosphere microbes under biological management, showing that plant cultivar and microbiome together influence below-ground growth, unlike under chemical management.

Constraints on the Emergence of RNA through Non-Templated Primer Extension with Mixtures of Potentially Prebiotic Nucleotides

This study investigates non-templated primer extension with alternative nucleotides to determine if RNA synthesis was biased against threo-nucleotides.

Altitude-dependent agro-ecologies impact the microbiome diversity of scavenging indigenous chicken in Ethiopia

The study examines how altitude-dependent agro-ecologies affect the microbiome diversity of scavenging indigenous chickens in Ethiopia, identifying environmental factors influencing microbial composition.

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity

This study evaluates how differentiation state and culture conditions affect the neuroregenerative bioactivity of extracellular vesicles (EVs) from neural stem/progenitor cells (NPSCs).

Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Genome-wide analysis reveals PhoP regulates pathogenicity in Riemerella anatipestifer

This study identifies PhoP as a key regulator of pathogenicity in Riemerella anatipestifer by combining DAP-seq and transcriptome analysis, showing its role in aerotolerance and virulence.

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography

The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.

ELI trifocal microscope: A precise cryogenic fabrication system to prepare target cryo-lamellae of cells for in situ cryo-ET study

The paper introduces ELI-TriScope, a cryogenic system for precise cryo-lamella preparation, achieving 100% success in targeting HeLa cell centrosomes for cryo-ET structural analysis.

Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation

This paper introduces autocyclase proteins that enable efficient self-cyclisation of peptides and proteins, producing cyclic biomolecules with high yields and avoiding challenges of enzymatic methods.

AIM1-dependent high basal SA accumulation modulates stomatal aperture in rice

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

MSD2, an apoplastic Mn-SOD, contributes to root skotomorphogenic growth by modulating ROS distribution in Arabidopsis

This study identifies MSD2, an apoplastic Mn-SOD in Arabidopsis, showing it modulates ROS distribution in roots during skotomorphogenic growth.

TGFβR Inhibition Represses TGF-β1 Initiated Keratin-7 Expression in Human Salivary Gland Progenitor Cells

The paper shows that TGFβR inhibition reduces K7 expression in hS/PCs while maintaining amylase, suggesting TGFβ signaling regulates K7 in salivary gland progenitor cells.

Sustained Released of Bioactive Mesenchymal Stromal Cell-Derived Extracellular Vesicles from 3D-Printed Gelatin Methacrylate Hydrogels

This study shows that mesenchymal stromal cell-derived extracellular vesicles can be incorporated into 3D-printed hydrogels to enable sustained release and retain bioactivity.

High expression of CD38 and MHC class II on CD8+ T cells during severe influenza disease reflects bystander activation and trogocytosis

This study investigates CD38 and MHC-II co-expression on CD8+ T cells during severe influenza, finding that it reflects bystander activation and trogocytosis from antigen-presenting cells, and is important for memory establishment.

Screening and Identification of Lujo Virus Entry Inhibitors from an FDA-Approved Drugs Library

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

Mechanism through which retrocyclin targets flavivirus multiplication

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

Screening of Botanical Drugs against SARS-CoV-2 Entry

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

This study identifies four residues in Lassa virus GP1 critical for receptor switch to LAMP1, showing their impact on binding affinity and infectivity.

Wzc and WcaJ mutations in hypervirulent Klebsiella pneumoniae lead to phage resistance at the cost of reduced virulence

This study identifies mutations in wzc and wcaJ genes in hypervirulent Klebsiella pneumoniae that confer phage resistance but reduce virulence.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

Structural insights into the activation of human calcium-sensing receptor

The paper presents cryo-EM structures of the human calcium-sensing receptor in inactive and active states, revealing structural changes during activation.

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer

This study identifies circMRPS35 as a factor promoting HCC progression and cisplatin resistance through miR-148a-3p sponging and a drug-induced peptide.

Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

The paper determines the crystal structure of the Drosophila SARM1 ARM domain using MIRAS phasing, revealing insights into its regulation and activation mechanism.

RNAi screening reveals requirement for PDGFRβ in JEV infection.

This study identifies PDGFRβ as a host factor required for JEV infection and shows that imatinib can protect against JEV by reducing viral load and histopathology.