Author

M. Strupp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

A. Galione· 3 shared F. M. Platt· 2 shared G. C. Churchill· 2 shared D. te Vruchte· 1 shared M. C. Patterson· 1 shared M. Factor· 1 shared M. Mann· 1 shared T. Bremova-Ertl· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. Galione

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Author profile →

3 papers

Recent·Most cited

Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT)

G. C. Churchill, M. Strupp, T. Bremova-Ertl, M. Factor, M. C. Patterson, F. M. Platt, A. Galione

This paper shows that N-acetyl-L-leucine is transported by organic anion transporters (OAT) instead of LAT, explaining its drug-like properties compared to L-leucine.

bioRxiv · Nov 12, 2020 · PreprintPharmacology & Toxicology

Effects of N-Acetyl-Leucine and its enantiomers in Niemann-Pick disease type C cells

D. te Vruchte, A. Galione, M. Strupp, M. Mann

This study evaluates the effects of N-Acetyl-Leucine and its enantiomers on lysosomal volume in NPC cells, finding that N-Acetyl-L-Leucine is most effective.

bioRxiv · Oct 31, 2019 · PreprintCell Biology

Unexpected differences in the pharmacokinetics of N-acetyl DL-leucine enantiomers after oral dosing and their clinical relevance

G. C. Churchill, M. Strupp, A. Galione, F. M. Platt

This study investigates the pharmacokinetic differences between enantiomers of N-acetyl-leucine after oral dosing in mice, finding that the D-enantiomer accumulates and has different tissue distribution compared to the L-enantiomer.

bioRxiv · Aug 16, 2019Pharmacology & Toxicology