ImmunologybioRxivPreprint
Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease
T. S. Mills, B. Kain, M. T. Burchill…·E. M. Pietras
The paper shows hematopoietic stem cells (HSCs) in a mouse model of chronic autoimmune disease serve as a long-term reservoir for trained immunity, with macrophages derived from them exhibiting increased inflammatory activity and reduced metabolic function.